Mitigating photo-induced artifacts on neural probes to understand CNS-related damage from space radiation

Shelita Renee' Hall; Min Hyuck Kim; Thong Chi Le; Hargsoon Yoon

doi:10.1117/12.2616025

18 April 2022 Mitigating photo-induced artifacts on neural probes to understand CNS-related damage from space radiation

Shelita Renee' Hall, Min Hyuck Kim, Thong Chi Le, Hargsoon Yoon

Proceedings Volume 12045, Nano-, Bio-, Info-Tech Sensors, and Wearable Systems 2022; 120450A (2022) https://doi.org/10.1117/12.2616025
Event: SPIE Smart Structures + Nondestructive Evaluation, 2022, Long Beach, California, United States

Abstract

A unique feature of the space radiation environment is the presence of high-energy charged (HZE) particles which may pose a health risk to astronauts. One of the greatest concerns is the possibility of radiation-induced deterioration of central nervous system (CNS) functions. Past research using rodent models has revealed that radiation exposure led to unexpected alterations in behavior where executive functions are compromised which are vital for facilitating the attainment of mission success. This research aims to study CNS-related damage on male and female animal models following radiation exposure. However, exposure to HZE particles will inevitably introduce radiation-induced artifacts during the in-vivo electrophysiological recording process. To accurately correlate altered neural activity observed with changes in behavior, the On-line Tool for the Assessment of Radiation in Space (OLTARIS) will confirm the materials needed to fabricate neural probes since they must be developed to withstand extreme, HZE environments. Successful results will help scientists to understand the effect radiation has on hippocampal and prefrontal cortex regions of the CNS to prove the onset of behavioral impairments by direct neural sensing. This will open new paths for developing shielding and pharmaceutical countermeasures against cosmic radiation effects detected during deep space exploration.

Conference Presentation

Citation Download Citation

Shelita Renee' Hall, Min Hyuck Kim, Thong Chi Le, and Hargsoon Yoon "Mitigating photo-induced artifacts on neural probes to understand CNS-related damage from space radiation", Proc. SPIE 12045, Nano-, Bio-, Info-Tech Sensors, and Wearable Systems 2022, 120450A (18 April 2022); https://doi.org/10.1117/12.2616025

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