Fabrication of biological detection chip based polymer nanostructures via nanoimprint lithography

Man Zhang; Cheng Shan; Liangping Xia; Suihu Dang; Mengting Zeng; Chunlei Du

doi:10.1117/12.2604943

24 November 2021 Fabrication of biological detection chip based polymer nanostructures via nanoimprint lithography

Man Zhang, Cheng Shan, Liangping Xia, Suihu Dang, Mengting Zeng, Chunlei Du

Proceedings Volume 12067, AOPC 2021: Biomedical Optics; 1206707 (2021) https://doi.org/10.1117/12.2604943
Event: Applied Optics and Photonics China 2021, 2021, Beijing, China

Abstract

High resolution and high precision polymer nanostructures has unique chemical and physical properties, playing an important role in nano-optics, nano-photonics, and high sensitivity biological detection. This paper demonstrated a novel fabrication method of biological detection chip based on polymer nanostructures via nanoimprint lithography. High precision nanostructures such as nanopillar arrays were prepared on chip film via nanoimprint lithography. The polymer nanostructures were used to enhance adhesion to cancer cells, which is low-cost and suitable for mass production. The replication polymer was biocompatibility materials that has no effect on cells. The experiment results show that the nanopillar arrays chip can adhere lung cancer cells in the size of 10-15 μm to achieve the purpose of filtering and detecting cells. Results of the experiments show that this new biological detection chip has potential applications of cancer detection, targeted therapy, food safety testing, and environmental monitoring.

Citation Download Citation

Man Zhang, Cheng Shan, Liangping Xia, Suihu Dang, Mengting Zeng, and Chunlei Du "Fabrication of biological detection chip based polymer nanostructures via nanoimprint lithography", Proc. SPIE 12067, AOPC 2021: Biomedical Optics, 1206707 (24 November 2021); https://doi.org/10.1117/12.2604943

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KEYWORDS

Polymers

Nanostructures

Nanolithography

Biological detection systems

Nanoimprint lithography

Lung cancer

Microfluidics

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