Application of VCSEL sensor chip integrating gold nanoparticles

Fang Cao; Xiaoqing Lv; Lei Bao; Pengying Chang; Liangchen Hu; Wenhui Jing

doi:10.1117/12.2644246

9 September 2022 Application of VCSEL sensor chip integrating gold nanoparticles

Fang Cao, Xiaoqing Lv, Lei Bao, Pengying Chang, Liangchen Hu, Wenhui Jing

Proceedings Volume 12328, Second International Conference on Optics and Image Processing (ICOIP 2022); 1232810 (2022) https://doi.org/10.1117/12.2644246
Event: Second International Conference on Optics and Image Processing (ICOIP 2022), 2022, Taian, China

Abstract

Biosensors have broad application prospects in biomedicine, pharmacy, chemical industry and environmental monitoring. Therefore, the research and development of biosensors has become a new hotspot in the development of science and technology in the world. A vertical cavity surface emitting laser (VCSEL) biosensor chip integrated with gold nanostructures is introduced in this paper. The chip mainly uses the packaging technology of semiconductor laser to realize the high integration of light source, hexagonal gold nanoparticle array, and detection system. We use anodic aluminum oxide film (AAO) as a mask to prepare hexagonal gold nanoparticle array, combined with a microfluidic chip to realize the sensing application that can be sensitive to the change of environmental solution. We modify the gold nanoparticles on the chip surface with specific antibodies, and then inject different concentrations of protein solution for detection. The output light power changes with the change of environmental solution, so as to detect the concentration and type of biological solution. The sensor has the advantages of low cost, high sensitivity, and high integration.

Citation Download Citation

Fang Cao, Xiaoqing Lv, Lei Bao, Pengying Chang, Liangchen Hu, and Wenhui Jing "Application of VCSEL sensor chip integrating gold nanoparticles", Proc. SPIE 12328, Second International Conference on Optics and Image Processing (ICOIP 2022), 1232810 (9 September 2022); https://doi.org/10.1117/12.2644246

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