Use of an indocyanine green nano-emulsion for the treatment of cutaneous melanoma by photothermal therapy

Letícia P. Martinelli; Gabriel Jasinevicius; Lilian Tan Moriyama; Hilde H. Buzzá; Juan Chen; Gang Zheng; Cristina Kurachi

doi:10.1117/12.2649420

14 March 2023 Use of an indocyanine green nano-emulsion for the treatment of cutaneous melanoma by photothermal therapy

Letícia P. Martinelli, Gabriel Jasinevicius, Lilian Tan Moriyama, Hilde H. Buzzá, Juan Chen, Gang Zheng, Cristina Kurachi

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Proceedings Volume 12352, Photonics in Dermatology and Plastic Surgery 2023; 1235207 (2023) https://doi.org/10.1117/12.2649420
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Melanoma is the most aggressive type of skin cancer with the highest mortality rate, with surgery being the standard treatment. In this study, the effect of indocyanine green nanoemulsion in an animal model was evaluated for the treatment of cutaneous melanoma, using photothermal therapy. Different irradiation protocols, and nanoICG intratumoral and systemic delivery ways were tested. Macroscopic and histological analyses and Kaplan-Meier curves for animal survival are presented for comparison of the different investigated protocols.

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Letícia P. Martinelli, Gabriel Jasinevicius, Lilian Tan Moriyama, Hilde H. Buzzá, Juan Chen, Gang Zheng, and Cristina Kurachi "Use of an indocyanine green nano-emulsion for the treatment of cutaneous melanoma by photothermal therapy", Proc. SPIE 12352, Photonics in Dermatology and Plastic Surgery 2023, 1235207 (14 March 2023); https://doi.org/10.1117/12.2649420

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