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17 March 2023 Fluorescence lifetime-enhanced tumor margin assessment in head and neck cancers using receptor targeted probes
Rahul Pal, Thinzar M. Lwin, Marisa E. Hom, Mark A. Varvares, Eben L. Rosenthal, Anand T.N. Kumar
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Proceedings Volume 12354, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2023; 123540E (2023) https://doi.org/10.1117/12.2649378
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Fluorescence imaging can result in poor tumor contrast due to non-specific probe accumulation of receptor targeted probes. Here we show using preclinical and clinical studies that fluorescence lifetime (FLT) imaging can significantly improve the sensitivity and specificity for tumor detection using epidermal growth factor receptor (EGFR) targeted near infrared probes. We also show that FLTs in tissue are highly correlated with receptor expression levels, thereby enabling quantification of receptor quantification in vivo. Ongoing efforts in our group towards the translation of FLT imaging for intraoperative image guidance during head and neck surgeries will also be discussed.
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Rahul Pal, Thinzar M. Lwin, Marisa E. Hom, Mark A. Varvares, Eben L. Rosenthal, and Anand T.N. Kumar "Fluorescence lifetime-enhanced tumor margin assessment in head and neck cancers using receptor targeted probes", Proc. SPIE 12354, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2023, 123540E (17 March 2023); https://doi.org/10.1117/12.2649378
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KEYWORDS
Tumors
Luminescence
Receptors
Cancer
Head
Neck
Near infrared
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