Photobiomodulation attenuates microglial activation by enhancing mitophagy

Wenjing Li; Xiaotong Gu; Feng Yue; Feifan Zhou

doi:10.1117/12.2647097

14 March 2023 Photobiomodulation attenuates microglial activation by enhancing mitophagy

Wenjing Li, Xiaotong Gu, Feng Yue, Feifan Zhou

Proceedings Volume 12362, Mechanisms of Photobiomodulation Therapy XVII; 1236209 (2023) https://doi.org/10.1117/12.2647097
Event: SPIE BiOS, 2023, San Francisco, California, United States

Conference Poster

Abstract

Neuroinflammation induced by activated microglia is a typical pathological feature in most neurodegenerative diseases. Generally, inhibition of neuroinflammation could attenuate damage of brain in neurodegenerative diseases. Photobiomodulation (PBM) has been proved to suppress neuroinflammation by decreasing microglial activation. However, the underlying mechanisms of PBM on microglial inflammation remain unclear. Herein, we studied the effects of mitochondrial function on PBM regulated microglial inflammation. The results showed that PBM attenuates lipopolysaccharide (LPS)-induced microglial proinflammatory response while ameliorating mitochondrial dysfunction. Further study revealed that PBM promotes mitophagy in microglia exposed to LPS. In addition, we found that 3- methyladenine (3-MA), the autophagy inhibitor, disrupts microglial mitophagy and reverses the protective effect of PBM on inflammation. Taken together, these studies underline the significance of mitophagy in suppressing inflammation and enhancing mitochondrial function in activated microglia under PBM treatment. Our research may supply a potential strategy to control the progression of neuroinflammation.

Citation Download Citation

Wenjing Li, Xiaotong Gu, Feng Yue, and Feifan Zhou "Photobiomodulation attenuates microglial activation by enhancing mitophagy", Proc. SPIE 12362, Mechanisms of Photobiomodulation Therapy XVII, 1236209 (14 March 2023); https://doi.org/10.1117/12.2647097

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available