Neurosurgery is the first line treatment for most malignancies of the brain however intraoperative healthy and diseased tissue differentiation often remains a challenge. We have demonstrated earlier that wide-field Muller Polarimetry Imaging (MPI) is a promising approach for brain tissue differentiation and fiber tracking. To examine the technique’s versatility in a similar to in vivo setting, we used our system to create maps of polarimetric properties for tissue differentiation in cadaveric animal brains under neurosurgery-like conditions. We present the effects of ultrasonic cavitation on optical response and examined the challenges of a complex topography and blood presence in a surgical resection cavity.
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Leonard Felger, Romain Gros, Theoni Maragkou, Richard McKinley, Stefano Moriconi, Michael Murek, Tatiana Novikova, Angelo Pierangelo, Omar Rodríguez-Núnez, Irena Zubak, Philippe Schucht, "Brain white matter fiber tracts identification using wide-field imaging Mueller polarimetry: Ex vivo studies in a surgery-like environment," Proc. SPIE 12364, Clinical and Translational Neurophotonics 2023, 1236406 (23 March 2023); https://doi.org/10.1117/12.2650106