A compact fluorescence sensor for low-cost non-invasive monitoring of gut permeability in undernutrition

Elena Monfort Sánchez; James Avery; Jonathan Gan; Jingjing Qian; Mulima Mwiinga; Rosemary Banda; Jonathan Hoare; Hutan Ashranfian; Ara Darzi; Paul Kelly; Alex Thompson

doi:10.1117/12.2649030

6 March 2023 A compact fluorescence sensor for low-cost non-invasive monitoring of gut permeability in undernutrition

Elena Monfort Sánchez, James Avery, Jonathan Gan, Jingjing Qian, Mulima Mwiinga, Rosemary Banda, Jonathan Hoare, Hutan Ashranfian, Ara Darzi, Paul Kelly, Alex Thompson

Author Affiliations +

Proceedings Volume 12369, Optics and Biophotonics in Low-Resource Settings IX; 1236904 (2023) https://doi.org/10.1117/12.2649030
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Undernutrition is associated with approximately 45% of deaths among children under the age of 5. Furthermore, in 2020, around 149 million children suffered impaired physical/cognitive development due to lack of adequate nutrition. Environmental enteropathy (EE) is associated with undernutrition and is characterized by a multifaceted breakdown in gut function, including an increase in intestinal permeability that can lead to inflammatory responses. However, the role and mechanisms associated with EE (particularly gut permeability) are not well understood. This is partly because current techniques to assess changes in gut permeability, such as endoscopic biopsies, histopathology and chemical tests such as Lactulose:Mannitol assays, are either highly invasive, unreliable or difficult to perform on specific groups of patients (such as infants and patients with urine retention problems). Therefore, low-cost, non-invasive and reliable diagnostic tools are urgently needed for better evaluation of intestinal permeability. Here, we present a compact transcutaneous fluorescence spectroscopy sensor for non-invasive evaluation of gut permeability and report the first in vivo data collected from volunteers in an undernutrition trial. Using this technique and device, fluorescence signals are detected transcutaneously after oral ingestion of a fluorescent solution. Preliminary results demonstrate the potential use of the presented sensor for clinical assessment of gut permeability in low-income settings.

Conference Presentation

Citation Download Citation

Elena Monfort Sánchez, James Avery, Jonathan Gan, Jingjing Qian, Mulima Mwiinga, Rosemary Banda, Jonathan Hoare, Hutan Ashranfian, Ara Darzi, Paul Kelly, and Alex Thompson "A compact fluorescence sensor for low-cost non-invasive monitoring of gut permeability in undernutrition", Proc. SPIE 12369, Optics and Biophotonics in Low-Resource Settings IX, 1236904 (6 March 2023); https://doi.org/10.1117/12.2649030

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