Morphine-mediated abnormal neuronal activation boosts mitochondrial fragmentation

Jie Rao; Xiaotong Gu; Jin Li; Zhichun Zhang; Feifan Zhou

doi:10.1117/12.2647093

14 March 2023 Morphine-mediated abnormal neuronal activation boosts mitochondrial fragmentation

Jie Rao, Xiaotong Gu, Jin Li, Zhichun Zhang, Feifan Zhou

Proceedings Volume 12380, Biophotonics and Immune Responses XVIII; 1238002 (2023) https://doi.org/10.1117/12.2647093
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Morphine addiction causes major medical and social problems worldwide. Chronic morphine exposure results in the development of behavioral sensitization, accompanied by the disruption of brain homeostasis. As a key brain reward region, nucleus accumbens (NAc) plays a central role in brain reward mechanisms. Furthermore, neurons in NAc are impaired by chronic morphine abuse, but the contribution of morphine exposure to neurons is poorly understood. Here we indicated that morphine-induced an abnormal neuronal activation in NAc. Critically, we found a remarkable increase of mitochondrial fragmentation in neurons following burst activity. Taken together, these results define the effects of morphine on neurons in NAc, and provide a new insight for development of future morphine addiction therapeutics.

Conference Presentation

Citation Download Citation

Jie Rao, Xiaotong Gu, Jin Li, Zhichun Zhang, and Feifan Zhou "Morphine-mediated abnormal neuronal activation boosts mitochondrial fragmentation", Proc. SPIE 12380, Biophotonics and Immune Responses XVIII, 1238002 (14 March 2023); https://doi.org/10.1117/12.2647093

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available