This PDF file contains the front matter associated with SPIE Proceedings Volume 12393, including the Title Page, Copyright information, Table of Contents, and Conference Committee information.

The low five year-survival rates for gastrointestinal cancers evidences a strong clinical need to improve their early detection. Current imaging methods for early detection are expensive and rely on white light imaging which lacks sufficient contrast to spot a wide range of potential tumours. Changes in absorption and reduced scattering coefficients can be linked to pre-cancerous abnormalities, such as Barrett’s Oesophagus, and invasive squamous cell carcinoma, in the oesophagus. Spatial Frequency Domain Imaging (SFDI) is a low-cost imaging technique from which quantitative maps of absorption and reduced scattering coefficients may be obtained using structured illumination. We have developed a clinically translatable, ultra-miniaturised SFDI system using optical fibers (0.125 mm diameter) to project structured illumination and a miniature camera (< 1 mm diameter) to capture the pattern response for a sample under test. The total package could therefore be made < 1.1mm diameter, representing, to the best of our knowledge, the smallest full SFDI probe achieved to date. We have demonstrated recovery of absorption and reduced scattering maps with our system for tissue mimicking co-polymer in oil phantoms of biologically relevant absorption and scattering properties. This technology represents a first step towards a less-invasive, cost-effective device which produces close to real-time absorption and reduced scattering maps for improved in vivo disease detection of the gastrointestinal tract.

With the development of SWIR sources and sensors for LIDAR and telecom applications, diffuse reflectance spectrometry (DRS) in the SWIR range (900-1600 nm) appears as a promising method for non-invasive measurement of glucose concentration in biological tissue. In particular, spatially resolved DRS (SRDRS) should address the main issue of such measurements, namely the layered nature of biological media. The following paper studies the feasibility of a SRDRS probe in the SWIR range for glucose measurement.

We report a fiber-optic-based ultrafast time-stretch laser detection and ranging (Lidar) sensor with 10 MHz speed and 10 μm accuracy with 30 mm dynamic range for head motion detection under the thermoplastic mask during image-guided radiotherapy procedures. The sensor (1) is miniaturized and fits under the mask, (2) is small enough not to cause attenuation in radiation beams, (3) has a spatial resolution of a tenth of a millimeter, (4) is real-time, and (5) is immune to electromagnetic radiation.