Evaluating the feasibility of using reduced scan length for non-contrast CT during image-guided liver ablations

Jun Hong; Erin Snoddy; A. Kyle Jones; Caleb S. O'Connor; Yuan-Mao Lin; Iwan Paolucci; Bruno C. Odisio; Kristy K. Brock

doi:10.1117/12.2655651

7 April 2023 Evaluating the feasibility of using reduced scan length for non-contrast CT during image-guided liver ablations

Jun Hong, Erin Snoddy, A. Kyle Jones, Caleb S. O'Connor, Yuan-Mao Lin, Iwan Paolucci, Bruno C. Odisio, Kristy K. Brock

Author Affiliations +

Proceedings Volume 12463, Medical Imaging 2023: Physics of Medical Imaging; 1246349 (2023) https://doi.org/10.1117/12.2655651
Event: SPIE Medical Imaging, 2023, San Diego, California, United States

Conference Poster

Abstract

Image guided percutaneous thermal ablation is widely used for patients with primary or secondary liver tumors who do not qualify for surgical resection. The COVER-ALL study is a randomized Phase II clinical trial that evaluates the impact of using software aid in confirming probe position and ablation coverage. Current practice in the trial involves acquisition of a pre-procedure contrast enhanced computed tomography (CECT) scan for gross tumor volume (GTV) definition and non-contrast CT after probe placement, followed by a biomechanical model-based deformable image registration (Morfeus) between the two scans to map the GTV onto the non-contrast CT for position confirmation. CT scan length that covers the entire liver is needed for Morfeus. In this work, we investigated an alternative workflow with a reduced length non-contrast CT using image padding on the first 50 COVER-ALL trial patients. The full-length non-contrast CT was first cropped to a fixed thickness, ranging from 2.5-7.5 cm, along the GTV. The remaining volume was padded with the CECT based on intensity-based deformable image registration (DIR). Morfeus DIR was performed between the CECT and resultant padded non-contrast CT to map the GTV segmentation from CECT to padded non-contrast CT. The GTV mapping results were compared to the original GTV mapping results performed on the full-length CT. The median mapping differences using cropping thickness of 7.5 cm was 1.2 (0.5-2.3) mm, with only 3 cases having larger than 5 mm discrepancies. The comparable DIR performance suggests the feasibility of acquiring a reduced-length non-contrast CT to maintain image registration accuracy.

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Jun Hong, Erin Snoddy, A. Kyle Jones, Caleb S. O'Connor, Yuan-Mao Lin, Iwan Paolucci, Bruno C. Odisio, and Kristy K. Brock "Evaluating the feasibility of using reduced scan length for non-contrast CT during image-guided liver ablations", Proc. SPIE 12463, Medical Imaging 2023: Physics of Medical Imaging, 1246349 (7 April 2023); https://doi.org/10.1117/12.2655651

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