Oxygenation imaging in deep tissue with X-ray Luminescence Computed Tomography (XLCT)

Yibing Zhang; Yile Fang; Vigjna Abbaraju; Sriparna Bhattacharya; Jeffrey N. Anker; Ge Wang; Changqing Li

doi:10.1117/12.2654446

10 April 2023 Oxygenation imaging in deep tissue with X-ray Luminescence Computed Tomography (XLCT)

Yibing Zhang, Yile Fang, Vigjna Abbaraju, Sriparna Bhattacharya, Jeffrey N. Anker, Ge Wang, Changqing Li

Proceedings Volume 12468, Medical Imaging 2023: Biomedical Applications in Molecular, Structural, and Functional Imaging; 124680I (2023) https://doi.org/10.1117/12.2654446
Event: SPIE Medical Imaging, 2023, San Diego, California, United States

Abstract

Oxygenation concentration of tissue is an important factor in culturing stem cells and in studying the therapy response of cancer cells. The hypoxia bone marrow is the site to harbor cancer cells. Thus, direct high-resolution measurements of molecular O₂ would provide powerful means of monitoring cultured stem cells and therapied cancer cells. We proposed an imaging approach to measure oxygenation concentration in deep tissues, based on the XLCT, with combined strengths of high chemical sensitivity and high spatial resolution. We have developed different biosensing films for oxygenation measurements and tested these films with X-ray luminescent experiments. We have also performed phantom experiments with multiple targets to validate the XLCT imaging system with measurements at two channels.

Conference Presentation

Citation Download Citation

Yibing Zhang, Yile Fang, Vigjna Abbaraju, Sriparna Bhattacharya, Jeffrey N. Anker, Ge Wang, and Changqing Li "Oxygenation imaging in deep tissue with X-ray Luminescence Computed Tomography (XLCT)", Proc. SPIE 12468, Medical Imaging 2023: Biomedical Applications in Molecular, Structural, and Functional Imaging, 124680I (10 April 2023); https://doi.org/10.1117/12.2654446

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