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Quantitative ultrasound (QUS) aims to find properties of scatterers which are related to the tissue microstructure. Among different QUS parameters, scatterer number density has been found to be a reliable biomarker to detect different abnormalities. The homodyned K-distribution (HK-distribution) is a model for the probability density function of the ultrasound echo amplitude that can model different scattering scenarios but requires a large number of samples to be estimated reliably. Parametric images of HK-distribution parameters can be formed by dividing the envelope data into small overlapping patches and estimating parameters within the patches independently. This approach imposes two limiting constraints: the HK-distribution parameters are assumed to be constant within each patch, and each patch requires enough independent samples. In order to mitigate those problems, we employ a deep learning approach to estimate parametric images of scatterer number density (related to HK-distribution shape parameter) without patching. Furthermore, an uncertainty map of the network’s prediction is quantified to provide insight about the confidence of the network about the estimated HK parameter values.
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Ali K. Z. Tehrani, Ivan M. Rosado-Mendez, Hayley Whitson, Hassan Rivaz, "A deep learning approach for patchless estimation of ultrasound quantitative parametric image with uncertainty measurement," Proc. SPIE 12470, Medical Imaging 2023: Ultrasonic Imaging and Tomography, 1247010 (10 April 2023); https://doi.org/10.1117/12.2651583