An automation sorting system for different DNA molecules based on microfluidic and dielectrophoresis technology

Si Di; Gong Zhang; Hai Yuan

doi:10.1117/12.2661166

16 December 2022 An automation sorting system for different DNA molecules based on microfluidic and dielectrophoresis technology

Si Di, Gong Zhang, Hai Yuan

Author Affiliations +

Proceedings Volume 12500, Fifth International Conference on Mechatronics and Computer Technology Engineering (MCTE 2022); 1250028 (2022) https://doi.org/10.1117/12.2661166
Event: 5th International Conference on Mechatronics and Computer Technology Engineering (MCTE 2022), 2022, Chongqing, China

Abstract

This paper presents a new sorting system for DNA molecules with different base pairs. In order to solve the problems of low sorting accuracy and low efficiency in traditional DNA sorting technology, microfluidic and dielectrophoresis technology is proposed to be used in this system. By use of the control ability on particle motion, a microfluidic chip is designed to establish a targeted DNA sorting microfluidic system. The flowing state of DNA solution and buffer in micro channel is simulated by multi physical field coupling software. The simulation results guide the design of microfluidic chip, and then realize the microfluidic chip through MEMS fabrication process. Through the research of relevant contents, the motion characteristics of DNA molecules in micro channels under the action of dielectrophoresis force are revealed. The experimental result indicates that the macromolecule DNA can be selected from the solution with different DNA molecules.

Citation Download Citation

Si Di, Gong Zhang, and Hai Yuan "An automation sorting system for different DNA molecules based on microfluidic and dielectrophoresis technology", Proc. SPIE 12500, Fifth International Conference on Mechatronics and Computer Technology Engineering (MCTE 2022), 1250028 (16 December 2022); https://doi.org/10.1117/12.2661166

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available