Air-jet based optical coherence elastography of brain tumor tissue: stiffness evaluation by structural histological analysis

Nicolas Detrez; Sazgar Burhan; Paul Strenge; Jessica Kren; Christian Hagel; Matteo Mario Bonsanto; Dirk Theisen-Kunde; Robert Huber; Ralf Brinkmann

doi:10.1117/12.2670944

11 August 2023 Air-jet based optical coherence elastography of brain tumor tissue: stiffness evaluation by structural histological analysis

Nicolas Detrez, Sazgar Burhan, Paul Strenge, Jessica Kren, Christian Hagel, Matteo Mario Bonsanto, Dirk Theisen-Kunde, Robert Huber, Ralf Brinkmann

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Proceedings Volume 12629, Emerging Technologies for Cell and Tissue Characterization II; 126290M (2023) https://doi.org/10.1117/12.2670944
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

An accurate tumor delineation in neurosurgery is still a very challenging problem which we are addressing with optical coherence elastography (OCE). Because of the highly viscoelastic properties of brain tissue, we developed a new Air-Jet based tissue excitation source and evaluated the tissue stiffness with a 3.2 MHz swept-source Optical Coherence Tomography (OCT) system with a line scan rate of 2.45 kHz. The phase based displacement per pixel is measured and stiffness maps are calculated for brain tumor samples. However, certain features in the stiffness maps are seemingly not correlatable to the tissue features in the histological sections. Therefore, the structural properties of the histological sections e.g. fiber orientation, cell nuclei concentration and the “onion structure” with their rotational direction for meningioma were given greater consideration. The structural information are extracted from the histological sections via color deconvolution and structural tensor analysis. First results show that the stiffness transitions correlate with some structures of the histological sections. In summary, the Air-Jet OCE seems to be capable of measuring the stiffness as well as the structural composition of the sample. The long-term aim of this project is to establish OCE to support tumor delineation in the field of neurosurgery.

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Nicolas Detrez, Sazgar Burhan, Paul Strenge, Jessica Kren, Christian Hagel, Matteo Mario Bonsanto, Dirk Theisen-Kunde, Robert Huber, and Ralf Brinkmann "Air-jet based optical coherence elastography of brain tumor tissue: stiffness evaluation by structural histological analysis", Proc. SPIE 12629, Emerging Technologies for Cell and Tissue Characterization II, 126290M (11 August 2023); https://doi.org/10.1117/12.2670944

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KEYWORDS

Tumors

Tissues

Brain tissue

Connective tissue

Elastography

Brain

Optical coherence

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