Morphologic analysis of the human tympanic membrane by polarization-sensitive OCT and polarized light microscopy

Svea Steuer; Joseph Morgenstern; Anett Jannasch; Lars Kirsten; Edmund Koch; Marcus Neudert; Jonas Golde

doi:10.1117/12.2675002

11 August 2023 Morphologic analysis of the human tympanic membrane by polarization-sensitive OCT and polarized light microscopy

Svea Steuer, Joseph Morgenstern, Anett Jannasch, Lars Kirsten, Edmund Koch, Marcus Neudert, Jonas Golde

Author Affiliations +

Proceedings Volume 12632, Optical Coherence Imaging Techniques and Imaging in Scattering Media V; 126320G (2023) https://doi.org/10.1117/12.2675002
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

The collagen layer of the human Tympanic Membrane (TM), which is essential for sound conduction and hearing, can be assessed in vivo by using endoscopic Polarization-Sensitive Optical Coherence Tomography (PS-OCT), as we have shown recently. Since the resolution of the utilized system was limited, an ex vivo validation of the structural information is presented here. By comparing higher resolution PS-OCT images of a temporal bone specimen and Polarized Light Microscopy (PLM) of histological slices from that TM with picrosirius red staining, the microstructure is investigated.

Citation Download Citation

Svea Steuer, Joseph Morgenstern, Anett Jannasch, Lars Kirsten, Edmund Koch, Marcus Neudert, and Jonas Golde "Morphologic analysis of the human tympanic membrane by polarization-sensitive OCT and polarized light microscopy", Proc. SPIE 12632, Optical Coherence Imaging Techniques and Imaging in Scattering Media V, 126320G (11 August 2023); https://doi.org/10.1117/12.2675002

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KEYWORDS

Optical coherence tomography

Polarized light

Ear

Polarization

Polarized microscopy

Tissues

In vivo imaging

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