A platform prototype for co-localized line-field confocal optical coherence tomography (LC-OCT) and confocal Raman microspectroscopy (CRM) acquisitions on ex vivo skin tissues

Léna Waszczuk; Jonas Ogien; Ali Tfayli; Jean-Luc Perrot; Arnaud Dubois

doi:10.1117/12.2672229

11 August 2023 A platform prototype for co-localized line-field confocal optical coherence tomography (LC-OCT) and confocal Raman microspectroscopy (CRM) acquisitions on ex vivo skin tissues

Léna Waszczuk, Jonas Ogien, Ali Tfayli, Jean-Luc Perrot, Arnaud Dubois

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Proceedings Volume 12632, Optical Coherence Imaging Techniques and Imaging in Scattering Media V; 1263210 (2023) https://doi.org/10.1117/12.2672229
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

Line-field Confocal Optical Coherence Tomography (LC-OCT) is a non-invasive optical technique for imaging the skin in vivo in depth and at high resolution. Confocal Raman Microspectroscopy (CRM) is a label-free technique that provides point-wise information on the molecular content of the analyzed sample. We present the development of a prototype platform allowing the co-localized acquisition of LC-OCT images and Raman spectra on ex vivo skin samples with an accuracy of ± 20 μm. We present results obtained on healthy skin as well as preliminary results obtained on a basal cell carcinoma surgery, aiming at identifying molecular tumor markers.

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Léna Waszczuk, Jonas Ogien, Ali Tfayli, Jean-Luc Perrot, and Arnaud Dubois "A platform prototype for co-localized line-field confocal optical coherence tomography (LC-OCT) and confocal Raman microspectroscopy (CRM) acquisitions on ex vivo skin tissues", Proc. SPIE 12632, Optical Coherence Imaging Techniques and Imaging in Scattering Media V, 1263210 (11 August 2023); https://doi.org/10.1117/12.2672229

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KEYWORDS

Confocal microscopy

Skin

Raman spectroscopy

Imaging spectroscopy

Optical coherence tomography

Prototyping

Tissues

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