Colorimetric fusion of attenuation and birefringence in OCT signatures: a screening tool for evaluating muscular degradation in alpha-sarcoglican deficit murine models

Verónica Mieites; Arturo Pardo; José A. Gutiérrez-Gutiérrez; Xavier Suárez-Calvet; José Miguel López-Higuera; Jordi Díaz-Manera; Olga M. Conde

doi:10.1117/12.2670555

11 August 2023 Colorimetric fusion of attenuation and birefringence in OCT signatures: a screening tool for evaluating muscular degradation in alpha-sarcoglican deficit murine models

Verónica Mieites, Arturo Pardo, José A. Gutiérrez-Gutiérrez, Xavier Suárez-Calvet, José Miguel López-Higuera, Jordi Díaz-Manera, Olga M. Conde

Author Affiliations +

Proceedings Volume 12632, Optical Coherence Imaging Techniques and Imaging in Scattering Media V; 1263211 (2023) https://doi.org/10.1117/12.2670555
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

In this work, intensity and polarization OCT were applied, simultaneously, to alpha-sarcoglycan deficit mice models, and a new visualization technique was implemented, based on encoding the attenuation and birefringence values in the HSV color space. Our samples consisted of 14 ex-vivo mice quadriceps at different disease stages (one, three, and six-month-old mice) and four healthy ones for reference. The healthy muscles present a different birefringence distribution to the dystrophic ones, while attenuation values for both kinds of samples lay in the same range. Nevertheless, the attenuation provides an increase in contrast and textural features that are not visible by only using birefringence, while the latter, encoded in the H coordinate, helps to easily identify damage inside the samples by color.

(2023) Published by SPIE. Downloading of the abstract is permitted for personal use only.

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Verónica Mieites, Arturo Pardo, José A. Gutiérrez-Gutiérrez, Xavier Suárez-Calvet, José Miguel López-Higuera, Jordi Díaz-Manera, and Olga M. Conde "Colorimetric fusion of attenuation and birefringence in OCT signatures: a screening tool for evaluating muscular degradation in alpha-sarcoglican deficit murine models", Proc. SPIE 12632, Optical Coherence Imaging Techniques and Imaging in Scattering Media V, 1263211 (11 August 2023); https://doi.org/10.1117/12.2670555

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KEYWORDS

RGB color model

Birefringence

Muscles

Attenuation

Optical coherence tomography

Visualization

Biological samples

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