Opto-electrochemical sensing of C-reactive protein using optical fiber lossy-mode resonance sensor

Dariusz Burnat; K. Szot-Karpińska; Petr Sezemsky; Monika Janik; Marcin Koba; Joanna Niedziółka-Jönsson; Viteszlav Stranak; Mateusz Śmietana

doi:10.1117/12.2678113

23 May 2023 Opto-electrochemical sensing of C-reactive protein using optical fiber lossy-mode resonance sensor

Dariusz Burnat, K. Szot-Karpińska, Petr Sezemsky, Monika Janik, Marcin Koba, Joanna Niedziółka-Jönsson, Viteszlav Stranak, Mateusz Śmietana

Author Affiliations +

Proceedings Volume 12643, European Workshop on Optical Fibre Sensors (EWOFS 2023); 126430X (2023) https://doi.org/10.1117/12.2678113
Event: European Workshop on Optical Fibre Sensors (EWOFS 2023), 2023, Mons, Belgium

Abstract

This work describes an experimental study towards label-free sensing of C-reactive protein (CRP) – a protein recognized as a inflammation marker. A multimode optical fiber with a section of its core coated with indium tin oxide (ITO) thin film was used as a sensor. ITO film allows for guiding lossy modes and can simultaneously be used as a transparent electrode for electrochemical measurements. Therefore, optical and electrochemical detection based on a single sensor was possible. Such a dual-domain approach is practical, especially when the results in one of the domains are not accurate enough, which was the case in this work. A case of different functionalization methods of ITO surface was also pointed out. The proposed sensor allows for recognition as low as ng/mL.

Citation Download Citation

Dariusz Burnat, K. Szot-Karpińska, Petr Sezemsky, Monika Janik, Marcin Koba, Joanna Niedziółka-Jönsson, Viteszlav Stranak, and Mateusz Śmietana "Opto-electrochemical sensing of C-reactive protein using optical fiber lossy-mode resonance sensor", Proc. SPIE 12643, European Workshop on Optical Fibre Sensors (EWOFS 2023), 126430X (23 May 2023); https://doi.org/10.1117/12.2678113

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