Wide-range pulsed parametric laser for drug identification

V. S. Airapetyan; A. V. Makeev

doi:10.1117/12.3007367

2 November 2023 Wide-range pulsed parametric laser for drug identification

V. S. Airapetyan, A. V. Makeev

Proceedings Volume 12920, XVI International Conference on Pulsed Lasers and Laser Applications; 129200M (2023) https://doi.org/10.1117/12.3007367
Event: XVI International Conference on Pulsed Lasers and Laser Applications, 2023, Tomsk, Russian Federation

Abstract

The use of modern nonlinear optical crystals (silver thiogalate (AgGaS2), etc.) as active media of optical resonators made it possible to develop and create a highly monochromatic (radiation width less than 1 cm-1) pulsed parametric laser with a wide tuning of the radiation wavelength (from 400 nm to 9100 nm). This paper reports on the operational (during one light pulse with a duration of 20 ns), local (laser spot diameter varies from 50 μm to 10 mm) and high-precision (error no more than 10%) determination of the composition, structure of molecules and their concentration of medicinal substances (drugs). The relevance of this problem is due to two reasons: the identification of counterfeit or poorly produced drugs and the demonstration of the possibility of a parametric laser in the fundamental study of the physicochemical properties of complex organic molecules, the natural vibration frequencies of which fall within the range of tuning the wavelength of pulsed radiation. parametric laser. In this work, a computer simulation of the process of resonant interaction of the radiation frequency of a tunable laser with the natural vibration frequencies of drug molecules was carried out. Using the described OPO, it is possible to register vibrational-rotational spectra, followed by mathematical processing and determination of the main physico-chemical parameters of the studied drug, by the method of differential absorption and scattering.

Citation Download Citation

V. S. Airapetyan and A. V. Makeev "Wide-range pulsed parametric laser for drug identification", Proc. SPIE 12920, XVI International Conference on Pulsed Lasers and Laser Applications, 129200M (2 November 2023); https://doi.org/10.1117/12.3007367

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