Application of exosome as a chemical drug carrier in tumour treatment

Jiayue Zhao; Xintong Zhoub

doi:10.1117/12.3013016

8 January 2024 Application of exosome as a chemical drug carrier in tumour treatment

Jiayue Zhao, Xintong Zhoub

Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 129241P (2024) https://doi.org/10.1117/12.3013016
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom

Abstract

Cancer is a disease that is difficult to cure completely at this stage, and how to treat it has been a research direction for many biomedical scientists. The use of exosomes to treat cancer is one of the key research areas at this stage. Based on chemotherapy and radiotherapy, which have a lot of side effects, exosomes can play an important role in drug delivery, conferring a tumor microenvironment, inhibiting tumor cells in a more targeted manner and minimizing the damage to normal human cells. This paper focuses on two existing experiments using exosomes to treat cancer - exosome delivery of paclitaxel for prostate cancer and exosome delivery of drugs for pancreatic cancer in mice - to investigate this current drug delivery route. A discussion of the tumor targeting of exosomes, their characteristics, exogenous loading and how they are induced to produce exosomes reveals that because they can be produced by the organism itself, they are more biocompatible and stable than conventional drug carriers and cause less immune system rejection. As a drug delivery route and drug carrier, exosomes are valuable for research in cancer therapy, but challenges remain in their clinical use.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Jiayue Zhao and Xintong Zhoub "Application of exosome as a chemical drug carrier in tumour treatment", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 129241P (8 January 2024); https://doi.org/10.1117/12.3013016

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