Eosinophils instance object segmentation on whole slide imaging using multi-label circle representation

Yilin Liu; Ruining Deng; Juming Xiong; Regina N. Tyree; Hernan Correa; Girish Hiremath; Yaohong Wang; Yuankai Huo

doi:10.1117/12.3005995

3 April 2024 Eosinophils instance object segmentation on whole slide imaging using multi-label circle representation

Yilin Liu, Ruining Deng, Juming Xiong, Regina N. Tyree, Hernan Correa, Girish Hiremath, Yaohong Wang, Yuankai Huo

Proceedings Volume 12933, Medical Imaging 2024: Digital and Computational Pathology; 129330I (2024) https://doi.org/10.1117/12.3005995
Event: SPIE Medical Imaging, 2024, San Diego, California, United States

Abstract

Eosinophilic esophagitis (EoE) is a chronic and relapsing disease characterized by esophageal inflammation. Symptoms of EoE include difficulty swallowing, food impaction, and chest pain which significantly impact the quality of life, resulting in nutritional impairments, social limitations, and psychological distress. The diagnosis of EoE is typically performed with a threshold (15 to 20) of eosinophils (Eos) per high-power field (HPF). Since the current counting process of Eos is a resource-intensive process for human pathologists, automatic methods are desired. Circle representation has been shown as a more precise, yet less complicated, representation for automatic instance cell segmentation such as CircleSnake approach. However, the CircleSnake was designed as a single-label model, which is not able to deal with multi-label scenarios. In this paper, we propose the multi-label CircleSnake model for instance segmentation on Eos. It extends the original CircleSnake model from a single-label design to a multi-label model, allowing segmentation of multiple object types. Experimental results illustrate the CircleSnake model’s superiority over the traditional Mask R-CNN model and DeepSnake model in terms of average precision (AP) in identifying and segmenting eosinophils, thereby enabling enhanced characterization of EoE. This automated approach holds promise for streamlining the assessment process and improving diagnostic accuracy in EoE analysis. The source code has been made publicly available at https://github.com/yilinliu610730/ EoE.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Yilin Liu, Ruining Deng, Juming Xiong, Regina N. Tyree, Hernan Correa, Girish Hiremath, Yaohong Wang, and Yuankai Huo "Eosinophils instance object segmentation on whole slide imaging using multi-label circle representation", Proc. SPIE 12933, Medical Imaging 2024: Digital and Computational Pathology, 129330I (3 April 2024); https://doi.org/10.1117/12.3005995

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