An ensemble learning method for detection of head and neck squamous cell carcinoma using polarized hyperspectral microscopic imaging

Hasan K. Mubarak; Ximing Zhou; Doreen Palsgrove; Baran D. Sumer; Amy Y. Chen; Baowei Fei

doi:10.1117/12.3007869

3 April 2024 An ensemble learning method for detection of head and neck squamous cell carcinoma using polarized hyperspectral microscopic imaging

Hasan K. Mubarak, Ximing Zhou, Doreen Palsgrove, Baran D. Sumer, Amy Y. Chen, Baowei Fei

Author Affiliations +

Proceedings Volume 12933, Medical Imaging 2024: Digital and Computational Pathology; 129330P (2024) https://doi.org/10.1117/12.3007869
Event: SPIE Medical Imaging, 2024, San Diego, California, United States

Abstract

Head and neck squamous cell carcinoma (HNSCC) has a high mortality rate. In this study, we developed a Stokes-vectorderived polarized hyperspectral imaging (PHSI) system for H&E-stained pathological slides with HNSCC and built a dataset to develop a deep learning classification method based on convolutional neural networks (CNN). We use our polarized hyperspectral microscope to collect the four Stokes parameter hypercubes (S0, S1, S2, and S3) from 56 patients and synthesize pseudo-RGB images using a transformation function that approximates the human eye’s spectral response to visual stimuli. Each image is divided into patches. Data augmentation is applied using rotations and flipping. We create a four-branch model architecture where each branch is trained on one Stokes parameter individually, then we freeze the branches and fine-tune the top layers of our model to generate final predictions. Our results show high accuracy, sensitivity, and specificity, indicating that our model performed well on our dataset. Future works can improve upon these results by training on more varied data, classifying tumors based on their grade, and introducing more recent architectural techniques.

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(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Hasan K. Mubarak, Ximing Zhou, Doreen Palsgrove, Baran D. Sumer, Amy Y. Chen, and Baowei Fei "An ensemble learning method for detection of head and neck squamous cell carcinoma using polarized hyperspectral microscopic imaging", Proc. SPIE 12933, Medical Imaging 2024: Digital and Computational Pathology, 129330P (3 April 2024); https://doi.org/10.1117/12.3007869

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