Piezoelectric sensors for use as a DNA probe

James G. Tsacoyeanes

doi:10.1117/12.21646

1 October 1990 Piezoelectric sensors for use as a DNA probe

James G. Tsacoyeanes

Proceedings Volume 1307, Electro-Optical Materials for Switches, Coatings, Sensor Optics, and Detectors; (1990) https://doi.org/10.1117/12.21646
Event: 1990 Technical Symposium on Optics, Electro-Optics, and Sensors, 1990, Orlando, FL, United States

Abstract

It will be shown that a quartz crystal coated with single strand DNA can act as a sensor for hybridization in liquids. The method used is based on the change in oscillating frequency resulting from the increase in mass on the crystal surface which is accompanying the hybridization. Specifically, it will be shown how an AT - cut quartz crystal oscillating at 5 MHz would operate as a DNA probe. Also a theoretical model will be presented which will show what the key physical parameters are, their interrelationships as well as their effect on measuring the inimobilization of DNA on a piezoelectric crystal.

Citation Download Citation

James G. Tsacoyeanes "Piezoelectric sensors for use as a DNA probe", Proc. SPIE 1307, Electro-Optical Materials for Switches, Coatings, Sensor Optics, and Detectors, (1 October 1990); https://doi.org/10.1117/12.21646

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