Paper
29 May 2024 4D dynamic contrast-enhanced breast CT: evaluation of quantitative accuracy
Juan J. Pautasso, Mikhail Mikerov, Liselot Goris, Koen Michielsen, Ioannis Sechopoulos
Author Affiliations +
Proceedings Volume 13174, 17th International Workshop on Breast Imaging (IWBI 2024); 131740W (2024) https://doi.org/10.1117/12.3026825
Event: 17th International Workshop on Breast Imaging (IWBI 2024), 2024, Chicago, IL, United States
Abstract
Four-dimensional dynamic contrast-enhanced breast CT (4D DCE-bCT) holds potential for high spatio-temporal-resolution imaging for characterization and monitoring of breast tumors. This study presents a dedicated phantom-based evaluation of the accuracy of dynamic iodine concentration quantification in 4D DCE-bCT. A breast CT (bCT) system was adapted for extended acquisition times, and the x-ray spectrum was optimized (65kV/0.25mm Cu). Additionally, reconstruction and correction algorithms were developed for accurate iodine quantification. The imaging sequence involved a 10-second pre-contrast scan with 360 projections, followed by two 100-second post-contrast scans, each with 400 projection images over 10 rotations, with 10 seconds between each scan. In this experiment, we aimed to quantitatively assess the changes in iodine concentration, while a time-varying concentration of iodine (range 0.5 to 10mg I/mL) was pumped through a 5mm diameter tube in an olive-oil breast phantom. Pre- and post-contrast images were scatter-corrected and reconstructed using a polychromatic iterative reconstruction (IMPACT) combined with PICCS. This process yielded a 38-framevirtual monoenergetic (30keV) image sequence at 5-second intervals. To verify the perfusion curve accuracy, a 5 × 5 × 10 voxel VOI was compared against the known true iodine concentration. Linear fits to the results showed good precision with some under-estimation of the true concentration (wash-in: slope = 0.7530, offset = +0.5208, R2 = 0.985; wash-out: slope = 1.012, offset = -0.8295, R2 = 0.987). These findings indicate the 4D DCE-bCT's potential to provide quantitatively accurate estimates of iodine concentration.
(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.
Juan J. Pautasso, Mikhail Mikerov, Liselot Goris, Koen Michielsen, and Ioannis Sechopoulos "4D dynamic contrast-enhanced breast CT: evaluation of quantitative accuracy", Proc. SPIE 13174, 17th International Workshop on Breast Imaging (IWBI 2024), 131740W (29 May 2024); https://doi.org/10.1117/12.3026825
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KEYWORDS
Iodine

Breast

Reconstruction algorithms

X-ray computed tomography

4D CT imaging

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