Automatic counting of chromosome fragments for the determination of radiation dose

Warren E. Smith; Billy C. Leung; James F. Leary

doi:10.1117/12.47790

1 April 1991 Automatic counting of chromosome fragments for the determination of radiation dose

Warren E. Smith, Billy C. Leung, James F. Leary

Proceedings Volume 1398, CAN-AM Eastern '90; (1991) https://doi.org/10.1117/12.47790
Event: CAN-AM Eastern '90: 1st Canadian-American Eastern Regional Conference on Applications of Optical Engineering, 1990, Rochester, NY, United States

Abstract

A correlation exists between chromosome breakage and radiation exposure so that counting chromosome fragments can provide a measure of the radiation dose to an organism. We describe our method for automatically counting prematurely condensed chromosome fragments from microscope images of the exploded nucleus. An alternative perhaps more promising non-imaging approach using flow karyotyping is also discussed. 1 .

Citation Download Citation

Warren E. Smith, Billy C. Leung, and James F. Leary "Automatic counting of chromosome fragments for the determination of radiation dose", Proc. SPIE 1398, CAN-AM Eastern '90, (1 April 1991); https://doi.org/10.1117/12.47790

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