Intercalation between antitumor anthracyclines and DNA as probed by resonance and surface-enhanced Raman spectroscopy

G. Smulevich; A. R. Mantini; M. Casu; M. P. Marzocchi

doi:10.1117/12.57339

1 May 1991 Intercalation between antitumor anthracyclines and DNA as probed by resonance and surface-enhanced Raman spectroscopy

G. Smulevich, A. R. Mantini, M. Casu, M. P. Marzocchi

Author Affiliations +

Proceedings Volume 1403, Laser Applications in Life Sciences; (1991) https://doi.org/10.1117/12.57339
Event: Laser Applications in Life Sciences, 1990, Moscow, Russian Federation

Abstract

The antiturnor anthracyclincs, idarubicin (IDA ), adrianiycin (ADM), epirubicin (EPI), carminomycin (CAR) and 1 1-deoxycarminornycin (DCM), whose siructural formula includes a substituted hydroxyanthraquirionc chrornophore and a sugar residue, form intercalation complexes with DNA. The stacking interaction between the chromophore and the base-pairs of DNA gives rise to noticeable ciTects on resonance Raman (RR) and surface-enhanced resonance Raman (SERRS) scattering as well as on the absorption (ABS), its second derivative (D2) and fluorescence emission (FEM) spectra.

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G. Smulevich, A. R. Mantini, M. Casu, and M. P. Marzocchi "Intercalation between antitumor anthracyclines and DNA as probed by resonance and surface-enhanced Raman spectroscopy", Proc. SPIE 1403, Laser Applications in Life Sciences, (1 May 1991); https://doi.org/10.1117/12.57339

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