Some applications of vibrational (Raman and FT/IR) spectroscopy to the study of biocompatibility in the ophthalmological field are described. The structure arid elastic properties of a new hydrophobic fluorocarbon copolymer (FCC) are presented. Bacterial adhesion on its surface is also considered. The structure arid properties of soft contact lenses based on poly2--hydroxyethylmethacrylate (PHEMA) and polyvinylpyrrolidone (PVP) are discussed in relation to their recent use as intrastromal implants. The preliminary results dealing with a study on protein deposits on soft contact lenses in presence of a collyrium limiting the formation of such deposits are also reported. 1.