Diagnosis of atherosclerotic tissue by resonance fluorescence spectroscopy

Walter Neu; Karl Konstantin Haase M.D.; Christian Tischler M.D.; Ralf Nyga; Karl R. Karsch M.D.

doi:10.1117/12.44014

1 May 1991 Diagnosis of atherosclerotic tissue by resonance fluorescence spectroscopy

Walter Neu, Karl Konstantin Haase M.D., Christian Tischler M.D., Ralf Nyga, Karl R. Karsch M.D.

Proceedings Volume 1425, Diagnostic and Therapeutic Cardiovascular Interventions; (1991) https://doi.org/10.1117/12.44014
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

Resonantly enhanced fluorescence emission induced by a tunable dye laser can be used for the identification of ablated atherosclerotic tissue. This method has been tested with anorganic samples exposed to air and to saline solution. A XeCl excimer laser pulse ((lambda) = 308 nm), delivered by a fused silica optical fiber, causes an efficient ablation of the irradiated samples. The wavelength of the narrow-band dye laser radiation is set to a strong transition of a specific species to be detected in the ablation plume. Taking into account the formation of the plume, the dye laser pulse is applied with a certain delay in order to excite resonantly the selected species in the plume. The resulting resonance fluorescence then is guided by optical fibers to an optical multi-channel analyzer system. Compared to the broad-band fluorescence during excimer laser ablation the resonance fluorescence signal shows a distinct and easily detectable sharp peak. The signal-to-background ratio is improved by one order of magnitude.

Citation Download Citation

Walter Neu, Karl Konstantin Haase M.D., Christian Tischler M.D., Ralf Nyga, and Karl R. Karsch M.D. "Diagnosis of atherosclerotic tissue by resonance fluorescence spectroscopy", Proc. SPIE 1425, Diagnostic and Therapeutic Cardiovascular Interventions, (1 May 1991); https://doi.org/10.1117/12.44014

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