Early detection of dysplasia in colon and bladder tissue using laser-induced fluorescence

Richard P. Rava; Rebecca R. Richards-Kortum; Maryann Fitzmaurice; Robert M. Cothren Jr.; Robert Petras; Michael J. Sivak Jr.; Howard H. Levine

doi:10.1117/12.44048

1 June 1991 Early detection of dysplasia in colon and bladder tissue using laser-induced fluorescence

Richard P. Rava, Rebecca R. Richards-Kortum, Maryann Fitzmaurice, Robert M. Cothren Jr., Robert Petras, Michael J. Sivak Jr., Howard H. Levine

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Proceedings Volume 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques; (1991) https://doi.org/10.1117/12.44048
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

Laser induced fluorescence has been explored as an early detection scheme for two clinically important examples of neoplasia: colorectal dysplasia and transitional cell carcinoma in the urinary bladder. In both, it is desirable to detect microscopic and biochemical changes of pre-cancer in order to identify patients at risk for developing invasive carcinoma. This paper will compare the fluorescence obtained from these two pre-cancerous conditions, and discuss the connection between the fluorescence and the morphological/molecular changes occurring in the tissue. The similarities and differences in the fluorescence will be compared to determine the general features of pre-cancerous changes that might be utilized for detection of the disease.

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Richard P. Rava, Rebecca R. Richards-Kortum, Maryann Fitzmaurice, Robert M. Cothren Jr., Robert Petras, Michael J. Sivak Jr., and Howard H. Levine "Early detection of dysplasia in colon and bladder tissue using laser-induced fluorescence", Proc. SPIE 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, (1 June 1991); https://doi.org/10.1117/12.44048

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