Investigation of the photodynamic properties of some chlorophyll a derivatives: the effect of doxorubicin on the chlorine e6 photosensitized death of Ehrlich carcinoma cells

V. Chekulayev; Igor Shevchuk; Anne Kahru; Virgo Th. Mihkelsoo; A. P. Kallikorm

doi:10.1117/12.27129

1 June 1991 Investigation of the photodynamic properties of some chlorophyll a derivatives: the effect of doxorubicin on the chlorine e₆ photosensitized death of Ehrlich carcinoma cells

V. Chekulayev, Igor Shevchuk, Anne Kahru, Virgo Th. Mihkelsoo, A. P. Kallikorm

Author Affiliations +

Proceedings Volume 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques; (1991) https://doi.org/10.1117/12.27129
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

The photodvnmtc prooerttes o+ ch1or.ne e trtmetnvi ester(Eá methyl pheophorbid a (MPh) and pheophvtin a (Ph) in Ehrllch carcinoma cells were investigatea ooth in vitro ana in vivo. Mu above mentioned ohotoseneitizere(PS) induced the hotoirradiated death o4 neoolaem cciii. There was an inverse relationshlo between the hvdroDhobictty of the PS and ite ohotodvnamic activity Uess hvbroahobic Eó was shown to be most eF4ective PSI'. ccoraina to our data irradiation of Ehrlici, carcinoma cefle in the oresence of E. causea a aramatic aecrease in ATP level. The latter could be connected with suporession of the intensity of anaerobic glvcolvsis ana conEumDtion of oxygen. It could be supposeb that a decrease in AlP level in Ehrlich carcinoma cells is mainly due to th irncouplinç of OxIdiitive phophory1aition. At the same time. upp1ementrv addition of doxorubicin a chemical decreaging thea functional activity of mitochondria) to E increased both in vitro and in vivo of phototoc i ci ty of Eo. The key rol e of an enerceti c status of tumour cells in their resistance to the photodynamic action is proposed.

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V. Chekulayev, Igor Shevchuk, Anne Kahru, Virgo Th. Mihkelsoo, and A. P. Kallikorm "Investigation of the photodynamic properties of some chlorophyll a derivatives: the effect of doxorubicin on the chlorine e₆ photosensitized death of Ehrlich carcinoma cells", Proc. SPIE 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, (1 June 1991); https://doi.org/10.1117/12.27129

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KEYWORDS

Tumors

Chlorine

Picosecond phenomena

Glucose

Cancer

Photodynamic therapy

In vitro testing

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