Pharmacokinetics of Photofrin II distribution in man

David Kessel; Unyime O. Nseyo M.D.; Veronique Schulz; Elizabeth Sykes

doi:10.1117/12.44057

1 June 1991 Pharmacokinetics of Photofrin II distribution in man

David Kessel, Unyime O. Nseyo M.D., Veronique Schulz, Elizabeth Sykes

Proceedings Volume 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques; (1991) https://doi.org/10.1117/12.44057
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

Plasma samples were obtained from 4 patients at intervals after administration of Photofrin II (2 mg/kg). Total porphyrin in plasma and protein/lipoprotein fractions was estimated after hydrolysis, and levels of different Photofrin II components were measured by HPLC. Pharmacokinetic data are provided relating to rates of loss of total porphyrin from plasma and to pool size and half-lives of sensitizers bound to albumin and lipoprotein fractions. Preferential persistence of the most hydrophobic components of Photofrin II was observed.

Citation Download Citation

David Kessel, Unyime O. Nseyo M.D., Veronique Schulz, and Elizabeth Sykes "Pharmacokinetics of Photofrin II distribution in man", Proc. SPIE 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, (1 June 1991); https://doi.org/10.1117/12.44057

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