Spectroscopic studies of second-generation sensitizers and their photochemical reactions in liposomes and cells

Benjamin Ehrenberg; Eitan Gross; Adina Lavi; Fred M. Johnson; Zvi Malik

doi:10.1117/12.44078

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1 June 1991 Spectroscopic studies of second-generation sensitizers and their photochemical reactions in liposomes and cells

Benjamin Ehrenberg, Eitan Gross, Adina Lavi, Fred M. Johnson, Zvi Malik

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Proceedings Volume 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques; (1991) https://doi.org/10.1117/12.44078
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

The photosensitization mechanism and kinetics of hematoporphyrin derivative (HPD), photofrin II (PF-II) and Zn2+-phthalocyanine tetrahydroxyl (ZnPC) are compared with the newly introduced sensitizers Zn2+ and Mg2+-tetrabenzoporphyrin (ZnTBP and MgTBP), in lipid vesicles. 9,10-dimethyl anthracene was used as a fluorescent target for singlet oxygen-mediated photosensitization. From the kinetics the quantum yield of singlet oxygen generation was calculated. MgTBP is compared with hematoporphyrin for the ability to photodamage bacterial cells and human cancer cells. MgTBP was found to have a comparable capacity for such a biological effect.

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Benjamin Ehrenberg, Eitan Gross, Adina Lavi, Fred M. Johnson, and Zvi Malik "Spectroscopic studies of second-generation sensitizers and their photochemical reactions in liposomes and cells", Proc. SPIE 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, (1 June 1991); https://doi.org/10.1117/12.44078

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