Syntheses of porphyrin and chlorin dimers for photodynamic therapy

Ravindra K. Pandey; M. Graca H. Vicente; Fuu-Yau Shiau; Thomas J. Dougherty; Kevin M. Smith

doi:10.1117/12.44076

1 June 1991 Syntheses of porphyrin and chlorin dimers for photodynamic therapy

Ravindra K. Pandey, M. Graca H. Vicente, Fuu-Yau Shiau, Thomas J. Dougherty, Kevin M. Smith

Proceedings Volume 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques; (1991) https://doi.org/10.1117/12.44076
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

Efficient methods for the syntheses of porphyrin and chlorin dimers joined with variable length carbon units, either at meso positions or at (beta) -pyrrolic positions, are described. The in vivo testing results for some of the dimers are also discussed. The main objective of this work is to understand the structure/activity relationships among carbon-carbon linked dimers of porphyrins and chlorins. It is anticipated that this study will assist the authors in designing photosensitizers with required chemical and photochemical properties.

Citation Download Citation

Ravindra K. Pandey, M. Graca H. Vicente, Fuu-Yau Shiau, Thomas J. Dougherty, and Kevin M. Smith "Syntheses of porphyrin and chlorin dimers for photodynamic therapy", Proc. SPIE 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, (1 June 1991); https://doi.org/10.1117/12.44076

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