1 May 1991 Detection and localization of absorbers in scattering media using frequency-domain principles
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Proceedings Volume 1431, Time-Resolved Spectroscopy and Imaging of Tissues; (1991) https://doi.org/10.1117/12.44186
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States
We report on time-resolved reflectance imaging experiments on a scattering medium containing a spatially limited absorber. The medium is illuminated at two positions with pulses from a mode-locked and cavity dumped picosecond dye laser. Time-resolved imaging of the back-scattered light is realized by means of a RF-phase-sensitive camera, synchronized to the laser pulses. The camera consists of a sinusoidally modulated proximity-focused image intensifier, a thermo-electrically cooled CCD camera, and a digital image processor unit. In operation, at least two images are taken under different image intensifier modulation conditions, such as modulation phase or modulation degree. By processing the stored images, a final image can be created the contrast of which is based only on time differences of the back-scattered photons. We found that this image reveals the presence and, to a certain extent, the position of a spatially limited absorber within the scattering medium. These experiments have been performed to evaluate possible ways towards an eventual optical tomography in living tissue.
© (1991) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Klaus W. Berndt, Klaus W. Berndt, Joseph R. Lakowicz, Joseph R. Lakowicz, } "Detection and localization of absorbers in scattering media using frequency-domain principles", Proc. SPIE 1431, Time-Resolved Spectroscopy and Imaging of Tissues, (1 May 1991); doi: 10.1117/12.44186; https://doi.org/10.1117/12.44186

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