Biochemical measurement of bilirubin with an evanescent wave optical sensor

Patrick Poscio; Christian D. Depeursinge; Y. Emery; Olivier M. Parriaux; Guy Voirin

doi:10.1117/12.47130

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1 September 1991 Biochemical measurement of bilirubin with an evanescent wave optical sensor

Patrick Poscio; Christian D. Depeursinge; Y. Emery; Olivier M. Parriaux; Guy Voirin

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Proceedings Volume 1510, Chemical and Medical Sensors; (1991) https://doi.org/10.1117/12.47130
Event: ECO4 (The Hague '91), 1991, The Hague, Netherlands

Abstract

Optical sensing techniques can be considered as powerful information sources on the biochemistry of tissue, blood, and physiological fluids. Various sensing modalities can be considered: spectroscopic determination of the fluorescence or optical absorption of the biological medium itself, or more generally, of a reagent in contact with the biological medium. The principle and realization of the optical sensor developed are based on the use of polished fibers: the cladding of a monomode fiber is removed on a longitudinal section. The device can then be inserted into an hypodermic needle for in-vivo measurements. Using this minute probe, local measurements of the tissue biochemistry or metabolic processes can be obtained. The sensing mechanism is based on the propagation of the evanescent wave in the tissues or reagent: the proximity of the fiber core allows the penetration of the model field tail into the sensed medium, with a uniquely defined field distribution. Single or multi-wavelength analysis of the light collected into the fiber yields the biochemical information. Here an example of this sensing technology is discussed. In-vitro measurement of bilirubin in gastric juice demonstrates that the evanescent wave optical sensor provides a sensitivity which matches the physiological concentrations. A device is proposed for in-vivo monitoring of bilirubin concentration in the gastro-oesophageal tract.

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Patrick Poscio, Christian D. Depeursinge, Y. Emery, Olivier M. Parriaux, and Guy Voirin "Biochemical measurement of bilirubin with an evanescent wave optical sensor", Proc. SPIE 1510, Chemical and Medical Sensors, (1 September 1991); https://doi.org/10.1117/12.47130

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