1 November 1991 Improved instrumentation for photodynamic fluorescence detection of cancer
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Abstract
A fluorescence-detection technique for cancer in human hollow organs has been developed based on endoscope-assisted two-wavelength excitation of the polyporphyrin Photofrin II in tissue. Due to the photosensitizing capability of the fluorescent tumormarket the applied dose is reduced to 0.4 mg/kg bw which avoids photosensitization of the patient''s skin. Fluorescence is detected either spectrally resolved by means of an optical multichannel analyzer or by imaging of diseased tissue areas with an intensified video system. The fluorescence pattern in the final image is presented with high contrast due to realtime subtraction of nonspecific background signals.
© (1991) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Reinhold Baumgartner, Reinhold Baumgartner, Peter Heil, Peter Heil, Dieter Jocham, Dieter Jocham, M. Kriegmair, M. Kriegmair, Herbert G. Stepp, Herbert G. Stepp, Eberhard Unsoeld, Eberhard Unsoeld, } "Improved instrumentation for photodynamic fluorescence detection of cancer", Proc. SPIE 1525, Future Trends in Biomedical Applications of Lasers, (1 November 1991); doi: 10.1117/12.48231; https://doi.org/10.1117/12.48231
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