Local interstitial hyperthermia in malignant brain tumors using a low-power Nd:YAG laser

Martin Bettag; Frank Ulrich; Thomas Kahn M.D.; William Rudolf Seitz

doi:10.1117/12.48229

1 November 1991 Local interstitial hyperthermia in malignant brain tumors using a low-power Nd:YAG laser

Martin Bettag, Frank Ulrich, Thomas Kahn M.D., William Rudolf Seitz

Proceedings Volume 1525, Future Trends in Biomedical Applications of Lasers; (1991) https://doi.org/10.1117/12.48229
Event: MedTech '91, 1991, Berlin, Germany

Abstract

Stereotactic laser-induced interstitial hyperthermia using a low power Nd:Y1G laser was performed in an experimental study on normal rat brain and on F-98 glial transplantation tumors. 1 new fiberoptic delivery system, the Interstitial Thermotherapy (ITT) laser fibre, was connected to a 1.06 um Nd:YPG laser and introduced stereotactically into the basal ganglia of the rat. Histological results of rat brains removed immediately after laser irradiation revealed a sharply demarcated lesion with a small peripheral edema. One week later, a typical necrosis became evident, while the edematous zone subsided by peripheral spread in the white matter. Four weeks following laser application, there was only a circumscribed cystic lesion without any effects in the periphery. Histological findings in the tumor model were similar. In first clinical trials, laser-induced hyperthermia was performed in patients with cerebral gliomas. Results were controlled by MR imaging and PET scan showing irreversible necrotic effects in the center of the tumor and reversible edematous changes in the periphery of the tumor. With the equipment used it is possible to map the spatial distribution of laser-tissue effects by "real time" MR imaging.

Citation Download Citation

Martin Bettag, Frank Ulrich, Thomas Kahn M.D., and William Rudolf Seitz "Local interstitial hyperthermia in malignant brain tumors using a low-power Nd:YAG laser", Proc. SPIE 1525, Future Trends in Biomedical Applications of Lasers, (1 November 1991); https://doi.org/10.1117/12.48229

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