Photoproduct formation of endogeneous protoporphyrin and its photodynamic activity

Karsten Koenig; Herbert Schneckenburger; Angelika C. Rueck; S. Auchter

doi:10.1117/12.48230

1 November 1991 Photoproduct formation of endogeneous protoporphyrin and its photodynamic activity

Karsten Koenig, Herbert Schneckenburger, Angelika C. Rueck, S. Auchter

Proceedings Volume 1525, Future Trends in Biomedical Applications of Lasers; (1991) https://doi.org/10.1117/12.48230
Event: MedTech '91, 1991, Berlin, Germany

Abstract

Human skin shows a strong autofluorescence in the red spectral region caused on the porphyrin production of the Gram positive lipophile skin bacterium Propionibacterium acnes. Irradiation of these bacteria reduces the integral fluorescence intensity and induces the formation of fluorescent photoproducts. The fluorescence band at around 670 nm and the decay times of around 1 ns and 5 ns are typical for protoporphyrin products. The photoproduct formation is connected with an increased absorption in the red spectral region. However the photodynamic activity of these photoproducts determined by scattering measurements on human erythrocytes is lower than that of protoporphyrin IX. 1:

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Karsten Koenig, Herbert Schneckenburger, Angelika C. Rueck, and S. Auchter "Photoproduct formation of endogeneous protoporphyrin and its photodynamic activity", Proc. SPIE 1525, Future Trends in Biomedical Applications of Lasers, (1 November 1991); https://doi.org/10.1117/12.48230

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