Antitumor therapeutic efficacy of photoactivated phthalocyanines ZnS4PC and AlS2PC in tumor-bearing mice

Gianfranco L. Canti; Rinaldo Cubeddu; Paola Taroni; Gianluca Valentini

doi:10.1117/12.136987

5 March 1993 Antitumor therapeutic efficacy of photoactivated phthalocyanines ZnS₄PC and AlS₂PC in tumor-bearing mice

Gianfranco L. Canti, Rinaldo Cubeddu, Paola Taroni, Gianluca Valentini

Proceedings Volume 1616, International Conference on Photodynamic Therapy and Laser Medicine; (1993) https://doi.org/10.1117/12.136987
Event: International Conference on Photodynamic Therapy and Laser Medicine, 1991, Beijing, China

Abstract

The photosensitizer of choice in photodynamic therapy (PDT) is the hematoporphyrin derivative (Hpd). However, Hpd has many characteristics which make it less than an ideal photosensitizer. The sulfonated phthalocyanines represent a new group of interesting compounds that have a strong absorption in the red part of the spectrum at 675 nm. In our laboratory we compare the efficacy of two phthalocyanines, the zincum tetrasulfonated (ZnS₄Pc) and the aluminum disulfonated (AlS₂Pc), on a murine tumor. Mice bearing MS-2 fibrosarcoma were treated with 5 or 25 mg/kg of ZnS₄Pc or AlS₂Pc and then the tumor mass was exposed to a laser light (100 mW for 10'). The results show that the treatment with AlS₂Pc is significantly more therapeutically active in respect to the treatment with the same dose of ZnS₄Pc. Moreover, resistance to rechallenge with the MS-2 tumor was evidenced by surviving animals. Studies are in progress with other murine tumors with different biological properties.

Citation Download Citation

Gianfranco L. Canti, Rinaldo Cubeddu, Paola Taroni, and Gianluca Valentini "Antitumor therapeutic efficacy of photoactivated phthalocyanines ZnS₄PC and AlS₂PC in tumor-bearing mice", Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); https://doi.org/10.1117/12.136987

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