Dosimetry for photodynamic therapy of malignant tumors

Lars Othar Svaasand

doi:10.1117/12.137060

5 March 1993 Dosimetry for photodynamic therapy of malignant tumors

Lars Othar Svaasand

Proceedings Volume 1616, International Conference on Photodynamic Therapy and Laser Medicine; (1993) https://doi.org/10.1117/12.137060
Event: International Conference on Photodynamic Therapy and Laser Medicine, 1991, Beijing, China

Abstract

The rationale of photodynamic therapy is based on the cytotoxic action of products generated by excited photosensitizers. Recent development has brought forward a series of promising photosensitizers ranging from hematoporphyrin derivative, various kinds of phthalocyanines and chlorins, to (delta) -aminolevulinic acid. The therapeutic efficacy is dependent on parameters such as tissue oxygenation, sensitizer distribution, drug clearance, optical irradiation, and exposure time. The general outline of a dosimetry model, which enables all these effects to be taken into account, is discussed.

Citation Download Citation

Lars Othar Svaasand "Dosimetry for photodynamic therapy of malignant tumors", Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); https://doi.org/10.1117/12.137060

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