Preventive effect of antihistaminics on mouse skin photosensitization with hematoporphyrin derivative

Nai-wu Fu; Li-xue Yan

doi:10.1117/12.137018

5 March 1993 Preventive effect of antihistaminics on mouse skin photosensitization with hematoporphyrin derivative

Nai-wu Fu, Li-xue Yan

Proceedings Volume 1616, International Conference on Photodynamic Therapy and Laser Medicine; (1993) https://doi.org/10.1117/12.137018
Event: International Conference on Photodynamic Therapy and Laser Medicine, 1991, Beijing, China

Abstract

Beta-carotene 100 mg/kg per day or vitamin C 50 mg/kg per day was administered orally for two days and did not prevent mouse skin photosensitization caused by hematoporphyrin derivative (HpD). However, (beta) -carotene 100 mg/kg per day administered intramuscularly for two days prevented mouse skin reaction. Cimetidine and benadryl 10 mg/kg per day, P.O.X 2, effectively prevented mouse skin reaction. This suggests histamine may be involved in skin photoreaction induced by HpD.

Citation Download Citation

Nai-wu Fu and Li-xue Yan "Preventive effect of antihistaminics on mouse skin photosensitization with hematoporphyrin derivative", Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); https://doi.org/10.1117/12.137018

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