14 August 1992 Near-IR Fourier transform Raman spectroscopy in surgery and medicine: ophthalmic applications
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Proceedings Volume 1644, Ophthalmic Technologies II; (1992) https://doi.org/10.1117/12.137431
Event: OE/LASE '92, 1992, Los Angeles, CA, United States
Abstract
This report describes the application of a recently developed spectroscopic technique, near- infrared-excited Fourier transform Raman scattering (abbreviated as near-IR FT-Raman) in the molecular-level characterization of normal and pathological human ocular tissues. The near-IR FT-Raman technique was shown to be particularly well-suited for the noninvasive analysis of intact ophthalmic samples because it exhibits such attractive features as complete fluorescence elimination, great sampling flexibility, high data acquisition speed, and measurement accuracy. For both intact human lenses and corneas, systematic FT-Raman studies were carried out in order to probe detailed molecular changes involved in cataract formation and cornea diseases. FT-Raman measurement was also made for synthetic biomaterials that can be attached to the corneal surface for laser refractive surgery. The technique of near-IR FT- Raman spectroscopy is potentially a nondestructive, non-invasive fingerprinting modality for monitoring lens aging, cataract formation, and corneal disease development.
© (1992) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Shuming Nie, Shuming Nie, Nai-Teng Yu, Nai-Teng Yu, Qiushi Ren, Qiushi Ren, } "Near-IR Fourier transform Raman spectroscopy in surgery and medicine: ophthalmic applications", Proc. SPIE 1644, Ophthalmic Technologies II, (14 August 1992); doi: 10.1117/12.137431; https://doi.org/10.1117/12.137431
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