1 June 1992 Improved photosensitizers for photodynamic therapy
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Abstract
In order to evaluate the effect of substituents in photosensitizing activity, a series of long wavelength absorbing photosensitizers related to pyropheophorbides, bacteriopheophorbides, and benzoporphyrin derivatives were synthesized. Pheophorbide dimers, covalently joining two molecules of pyropheophorbide-a and bacteriopheophorbide-a with lysine as a cross-link were also prepared. The syntheses and spectroscopic properties of these compounds are discussed. Some of these compounds were tested for in vivo photosensitizing activity vis-a-vis Photofrin IITM, using the standard screening system of DBA/2 mice bearing transplanted SMT/F tumors. The preliminary in vivo results suggest that replacement of substituents at peripheral positions of the macrocycles causes a significant difference in photosensitizing efficacy.
© (1992) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Ravindra K. Pandey, Ravindra K. Pandey, Fuu-Yau Shiau, Fuu-Yau Shiau, Isabelle Meunier, Isabelle Meunier, Subbaraya Ramaprasad, Subbaraya Ramaprasad, Adam B. Sumlin, Adam B. Sumlin, Thomas J. Dougherty, Thomas J. Dougherty, Kevin M. Smith, Kevin M. Smith, } "Improved photosensitizers for photodynamic therapy", Proc. SPIE 1645, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy, (1 June 1992); doi: 10.1117/12.60948; https://doi.org/10.1117/12.60948
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