Development and experimental in-vivo evaluation of mathematical modeling of coagulation by laser

Claire Beacco; Serge R. Mordon; Jean Marc Brunetaud

doi:10.1117/12.137453

Abstract

Most clinical procedures using lasers are based on thermal laser-tissue interactions resulting in tissue damage. A mathematical model allowing temperature and damage prediction would be a useful tool to choose laser parameters able to produce the damage required. This study aimed at the development of a model called HELIOS. The capability of the model to predict thermal coagulation was evaluated by comparison with experimental in-vivo results. Conversion of laser light in tissue was studied using a beam broadening model, which is typically a modification of Beer-Lambert's law and takes into account scattering of light in tissue. HELIOS was validated making experimental studied in-vivo on liver (homogeneous tissue) of rats using a CW Nd:YAG laser, a CO₂ laser, and an Argon laser. For a given set of laser parameters, temperature measurements were performed using an infrared camera (Agema, Sweden). The histological examination was carried out on samples to quantify the depth of coagulation necrosis. Experimental data obtained in-vivo were compared with those calculated previously using HELIOS and similar sets of parameters. The difference between the predicted temperature evolution on tissue surface and that measured by the infrared camera was less than 5 degree(s)C in all cases. The difference between the predicted coagulation necrosis depth and the corresponding experimental one was less than 10%. In conclusion, HELIOS allows good prediction of tissue temperature and coagulation necrosis. This model appears sufficiently precise for clinical applications and so should be well adapted to control thermal action of lasers in biological tissues.

Citation Download Citation

Claire Beacco, Claire Beacco, Serge R. Mordon, Serge R. Mordon, Jean Marc Brunetaud, Jean Marc Brunetaud, } "Development and experimental in-vivo evaluation of mathematical modeling of coagulation by laser", Proc. SPIE 1646, Laser-Tissue Interaction III, (7 August 1992); doi: 10.1117/12.137453; https://doi.org/10.1117/12.137453

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