Monitoring photochemistry in tissue using frequency domain photon migration

Tsong-Tseh Tsay; Bruce J. Tromberg; Eric H. Cho; Khai T. Vu; Lars Othar Svaasand

doi:10.1117/12.137461

7 August 1992 Monitoring photochemistry in tissue using frequency domain photon migration

Tsong-Tseh Tsay, Bruce J. Tromberg, Eric H. Cho, Khai T. Vu, Lars Othar Svaasand

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Proceedings Volume 1646, Laser-Tissue Interaction III; (1992) https://doi.org/10.1117/12.137461
Event: OE/LASE '92, 1992, Los Angeles, CA, United States

Abstract

Frequency domain photon migration (FDPM) non-invasively investigates the optical properties of multiple-scattering media such as tissue. In this work, FDPM is used to examine the optical properties of an EMT-6 murine tumor model in Balb/c mice. In-vivo measurements are recorded before and after intravenous administration of the photosensitizer, chloroaluminum tetra-sulfonated phthalocyanine (CASPc). Optical properties are used to: (1) discriminate between tumor and healthy tissue and (2) monitor the rate of tumor drug uptake. Our data show substantial frequency-dependent contrast between tumor and normal tissue. In addition, drug pharmacokinetics are effectively recorded in situ. Although FDPM can quantitatively measure absorption and scattering coefficients in infinite homogeneous media, exact values of these optical properties are difficult to extract in vivo due to boundary condition uncertainties.

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Tsong-Tseh Tsay, Bruce J. Tromberg, Eric H. Cho, Khai T. Vu, and Lars Othar Svaasand "Monitoring photochemistry in tissue using frequency domain photon migration", Proc. SPIE 1646, Laser-Tissue Interaction III, (7 August 1992); https://doi.org/10.1117/12.137461

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KEYWORDS

Tumors

Tissues

Optical properties

Tissue optics

Absorption

Scattering

Laser tissue interaction

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