7 August 1992 Photochemical effects of chloroaluminum-sulfonated phthalocyanine in arteries with intimal hyperplasia
Author Affiliations +
Proceedings Volume 1646, Laser-Tissue Interaction III; (1992); doi: 10.1117/12.137458
Event: OE/LASE '92, 1992, Los Angeles, CA, United States
Abstract
The present study uses photodynamic therapy (PDT) for the treatment of IH in the rat carotid artery model. PDT is a relatively new cancer treatment technique which utilizes light-activated photosensitizers (PS) to produce injury to targeted cells. PS have no cytotoxic effects unless they are activated by the appropriate wavelength of light. Upon absorption of a photon, the activated PS can either by directly cytotoxic or give rise to cytotoxic oxygen species, commonly singlet oxygen, via energy transfer to the ground state molecular oxygen. Singlet oxygen then becomes the mediator of cellular injury by affecting cellular membranes and subcellular organelles.
© (1992) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Paolo Ortu, Glenn M. LaMuraglia, Walter Gregory Roberts, Kevin T. Schomacker, Thomas F. Deutsch, Thomas J. Flotte, Tayyaba Hasan, "Photochemical effects of chloroaluminum-sulfonated phthalocyanine in arteries with intimal hyperplasia", Proc. SPIE 1646, Laser-Tissue Interaction III, (7 August 1992); doi: 10.1117/12.137458; https://doi.org/10.1117/12.137458
PROCEEDINGS
7 PAGES


SHARE
KEYWORDS
Arteries

Simulation of CCA and DLA aggregates

Picosecond phenomena

Luminescence

Photodynamic therapy

Oxygen

Injuries

Back to Top