16 April 1992 Continuous arterial blood gas monitoring in rabbits: an efficient method for evaluation of ratio-based optrodes
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Abstract
Laboratory bench testing of optical blood gas sensors is insufficient to completely predict capabilities. Sensor testing in animals offers advantages of known physiologic and regulatory mechanisms of hemodynamics to better predict sensor performance. The domestic rabbit, Oryctalogis Cuniculus, a lagomorph of the family Leporidae was used for sensor evaluation. The rabbits are ventilated and blood gases modulated by variations in FIO2 and rate adjustments. Twenty gauge catheters are placed in the dorsal aorta, cartoid, and femoral arteries. Pressures are monitored via transducers on the arterial lines. The optical blood gas sensors are fitted within the catheters and blood samples are collected over them for bench analysis. Sensors are on 125 micrometers glass optic fibers. Proprietary prepolymers are applied on the fiber tips through in fiber photopolymerization. These sensors are then calibrated in tonometered water and blood. Sensor monitoring is accomplished through OSR microfluorimetry systems. We have used this model in 26 studies over the past six months evaluating over fifty blood gas sensors. These studies have lasted from six to twenty-four hours. Our correlation of sensor readings to assayed blood samples is r2 equals .97 for pH values of 6.80 - 7.70, r2 equals .94 for PCO2 values of 10 - 175 mmHg and r2 equals .94 for PO2 values of 10 - 350 mmHg.
© (1992) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Roy C. Martin, Alan D. Olstein, Stephen F. Malin, and Anne Perkovich "Continuous arterial blood gas monitoring in rabbits: an efficient method for evaluation of ratio-based optrodes", Proc. SPIE 1648, Fiber Optic Medical and Fluorescent Sensors and Applications, (16 April 1992); doi: 10.1117/12.58307; https://doi.org/10.1117/12.58307
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