Fiber optic probes for tissue illumination in photodynamic diagnosis and therapy

Reinhold Baumgartner; Wolfgang Beyer; G. Friedsam; Dieter Jocham; Axel Noack; Ronald Sroka; Herbert G. Stepp; Eberhard Unsoeld

doi:10.1117/12.60226

1 August 1992 Fiber optic probes for tissue illumination in photodynamic diagnosis and therapy

Reinhold Baumgartner, Wolfgang Beyer, G. Friedsam, Dieter Jocham, Axel Noack, Ronald Sroka, Herbert G. Stepp, Eberhard Unsoeld

Author Affiliations +

Proceedings Volume 1649, Optical Fibers in Medicine VII; (1992) https://doi.org/10.1117/12.60226
Event: OE/LASE '92, 1992, Los Angeles, CA, United States

Abstract

Photodynamic diagnosis (PDD) and therapy (PDT) require light application devices which enable homogeneous illumination of tissue in hollow organs. Three techniques based on modification of the aperture of single fibers are presented mainly for use in urology and pneumology in combination with rigid and flexible endoscopes. All illumination systems allow for nearly entire illumination of the endoscope's viewing field. A microlens system is used for fluorescence diagnostic purposes in the lung. The system, consisting of two plano convex lenses in a condenser configuration, is attached directly to the fiber. The beam profile is optimized by ray tracing calculations. For fluorescence excitation of the tumormarker Photofrin II in the urinary bladder a 500 micrometers plastic fiber is used. The tip of the fiber is polished to a double cone with angles of 12 degree(s) and 7 degree(s). With this modification the aperture is increased by a factor of two. Photodynamic treatment of confined superficial tumors in the lung was successfully performed with a fused silica fiber coupled to the endoscope in a special adaptive device. In this procedure laserlight at 630 nm is guided through the optics channel of rigid endoscopes. A homogeneous circular illumination pattern is obtained following exactly the deflection angle of the endoscope.

Citation Download Citation

Reinhold Baumgartner, Wolfgang Beyer, G. Friedsam, Dieter Jocham, Axel Noack, Ronald Sroka, Herbert G. Stepp, and Eberhard Unsoeld "Fiber optic probes for tissue illumination in photodynamic diagnosis and therapy", Proc. SPIE 1649, Optical Fibers in Medicine VII, (1 August 1992); https://doi.org/10.1117/12.60226

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available