Photosensitized inactivation of infectious agents for sterilization of red blood cell concentrates and whole blood

Millard M. Judy; James Lester Matthews; Franklin M. Sogandares-Bernal; Joseph T. Newman; Tran C. Chanh; Alain J. Marengo-Rowe

doi:10.1117/12.137507

1 June 1992 Photosensitized inactivation of infectious agents for sterilization of red blood cell concentrates and whole blood

Millard M. Judy, James Lester Matthews, Franklin M. Sogandares-Bernal, Joseph T. Newman, Tran C. Chanh, Alain J. Marengo-Rowe

Author Affiliations +

Proceedings Volume 1650, Medical Lasers and Systems; (1992) https://doi.org/10.1117/12.137507
Event: OE/LASE '92, 1992, Los Angeles, CA, United States

Abstract

More than 10 million units of human blood components are transfused annually in the United States. Although donor screening and testing have greatly lowered the risk of transmission of viral and protozoan infectious agents, additional sterilization procedures which also preserve blood component function would be of significant value. Use of visible-light-range photosensitizers for sterilization of red blood cells is currently being aggressively investigated in laboratory-scale optical-mechanical systems. Both the photochemical sterilization process and the optical-mechanical system must operate without introducing significant alteration in the properties of the red cells. With successful demonstration of the efficacy and safety of these sterilization techniques, implementation in the blood bank setting will require scale-up to optical-mechanical systems capable of handling approximately 50,000 units daily in 500 - 1,000 blood banks in the United States.

Citation Download Citation

Millard M. Judy, James Lester Matthews, Franklin M. Sogandares-Bernal, Joseph T. Newman, Tran C. Chanh, and Alain J. Marengo-Rowe "Photosensitized inactivation of infectious agents for sterilization of red blood cell concentrates and whole blood", Proc. SPIE 1650, Medical Lasers and Systems, (1 June 1992); https://doi.org/10.1117/12.137507

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available